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The glutamate/cystine antiporter SLC7A11/xCT enhances cancer cell dependency on glucose by exporting glutamate

Cancer cells with specific genetic alterations may be highly dependent on certain nutrients for survival, which can inform therapeutic strategies to target these cancer-specific metabolic vulnerabilities. The glutamate/cystine antiporter solute carrier family 7 member 11 (SLC7A11, also called xCT) i...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Koppula, Pranavi, Zhang, Yilei, Shi, Jiejun, Li, Wei, Gan, Boyi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572906/
https://ncbi.nlm.nih.gov/pubmed/28630042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.798405
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