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Cystine uptake through the cystine/glutamate antiporter xCT triggers glioblastoma cell death under glucose deprivation
Oncogenic signaling in cancer cells alters glucose uptake and utilization to supply sufficient energy and biosynthetic intermediates for survival and sustained proliferation. Oncogenic signaling also prevents oxidative stress and cell death caused by increased production of reactive oxygen species....
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| Pubblicato in: | J Biol Chem |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5712613/ https://ncbi.nlm.nih.gov/pubmed/29038291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.814392 |
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