SHP2 Inhibition Prevents Adaptive Resistance to MEK inhibitors in Multiple Cancer Models

Adaptive resistance to MEK inhibitors (MEK-Is) typically occurs via induction of genes for different receptor tyrosine kinases (RTKs) and/or their ligands, even in tumors of the same histotype, making combination strategies challenging. SHP2 (PTPN11) is required for RAS/ERK pathway activation by mos...

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Dettagli Bibliografici
Pubblicato in:Cancer Discov
Autori principali: Fedele, Carmine, Ran, Hao, Diskin, Brian, Wei, Wei, Jen, Jayu, Geer, Mitchell, Araki, Kiyomi, Ozerdem, Ugur, Simeone, Diane M, Miller, George, Neel, Benjamin G, Tang, Kwan Ho
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6170706/
https://ncbi.nlm.nih.gov/pubmed/30045908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-0444
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