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Off‐target inhibition by active site‐targeting SHP2 inhibitors
Due to the involvement of SHP2 (SH2 domain‐containing protein‐tyrosine phosphatase) in human disease, including Noonan syndrome and cancer, several inhibitors targeting SHP2 have been developed. Here, we report that the commonly used SHP2 inhibitor NSC‐87877 does not exhibit robust inhibitory effect...
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| Udgivet i: | FEBS Open Bio |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
John Wiley and Sons Inc.
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6120237/ https://ncbi.nlm.nih.gov/pubmed/30186742 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12493 |
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