טוען...
Off‐target inhibition by active site‐targeting SHP2 inhibitors
Due to the involvement of SHP2 (SH2 domain‐containing protein‐tyrosine phosphatase) in human disease, including Noonan syndrome and cancer, several inhibitors targeting SHP2 have been developed. Here, we report that the commonly used SHP2 inhibitor NSC‐87877 does not exhibit robust inhibitory effect...
שמור ב:
| הוצא לאור ב: | FEBS Open Bio |
|---|---|
| Main Authors: | , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
John Wiley and Sons Inc.
2018
|
| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6120237/ https://ncbi.nlm.nih.gov/pubmed/30186742 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12493 |
| תגים: |
הוספת תג
אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!
|