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SHP2 Inhibition Prevents Adaptive Resistance to MEK inhibitors in Multiple Cancer Models
Adaptive resistance to MEK inhibitors (MEK-Is) typically occurs via induction of genes for different receptor tyrosine kinases (RTKs) and/or their ligands, even in tumors of the same histotype, making combination strategies challenging. SHP2 (PTPN11) is required for RAS/ERK pathway activation by mos...
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| Publicado no: | Cancer Discov |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6170706/ https://ncbi.nlm.nih.gov/pubmed/30045908 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-0444 |
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