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Sticking It to Cancer With Molecular Glue For SHP2
Much effort has been expended to develop inhibitors against protein-tyrosine phosphatases (PTPs), nearly all of it unsuccessful. A recent report, describing a highly specific, orally bioavailable inhibitor of the PTP oncoprotein SHP2 with in vivo activity, suggests that allostery might provide a way...
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| Publicado no: | Cancer Cell |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5558882/ https://ncbi.nlm.nih.gov/pubmed/27505669 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.07.010 |
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