Leucine-rich repeat containing 8A (LRRC8A)–dependent volume-regulated anion channel activity is dispensable for T-cell development and function

BACKGROUND: Leucine-rich repeat containing 8A (LRRC8A) is an ubiquitously expressed transmembrane protein with 17 leucine-rich repeats (LRRs) at its C-terminal end and is an essential component of the volume-regulated anion channel (VRAC), which controls cellular volume. A heterozygous mutation in L...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:J Allergy Clin Immunol
Huvudupphovsmän: Platt, Craig D., Chou, Janet, Houlihan, Patrick, Badran, Yousef R., Kumar, Lalit, Bainter, Wayne, Poliani, P. Luigi, Perez, Carlos J., Dent, Sharon Y. R., Clapham, David E., Benavides, Fernando, Geha, Raif S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6170198/
https://ncbi.nlm.nih.gov/pubmed/28192143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2016.12.974
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk