The LRRC8A Mediated “Swell Activated” Chloride Conductance Is Dispensable for Vacuolar Homeostasis in Neutrophils

The dialysis of human and mouse neutrophils in patch clamp experiments in the conventional whole-cell mode induces the emergence of a chloride (Cl(-)) current that appeared to be primarily regulated by cytoplasmic ionic strength. The characteristics of this current resembled that of the classical, a...

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Pubblicato in:Front Pharmacol
Autori principali: Behe, Philippe, Foote, Juliet R., Levine, Adam P., Platt, Craig D., Chou, Janet, Benavides, Fernando, Geha, Raif S., Segal, Anthony W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2017
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5427109/
https://ncbi.nlm.nih.gov/pubmed/28553230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00262
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