Leucine-rich repeat containing 8A (LRRC8A)–dependent volume-regulated anion channel activity is dispensable for T-cell development and function

BACKGROUND: Leucine-rich repeat containing 8A (LRRC8A) is an ubiquitously expressed transmembrane protein with 17 leucine-rich repeats (LRRs) at its C-terminal end and is an essential component of the volume-regulated anion channel (VRAC), which controls cellular volume. A heterozygous mutation in L...

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Dades bibliogràfiques
Publicat a:J Allergy Clin Immunol
Autors principals: Platt, Craig D., Chou, Janet, Houlihan, Patrick, Badran, Yousef R., Kumar, Lalit, Bainter, Wayne, Poliani, P. Luigi, Perez, Carlos J., Dent, Sharon Y. R., Clapham, David E., Benavides, Fernando, Geha, Raif S.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6170198/
https://ncbi.nlm.nih.gov/pubmed/28192143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2016.12.974
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