Leucine-rich repeat containing 8A (LRRC8A)–dependent volume-regulated anion channel activity is dispensable for T-cell development and function

BACKGROUND: Leucine-rich repeat containing 8A (LRRC8A) is an ubiquitously expressed transmembrane protein with 17 leucine-rich repeats (LRRs) at its C-terminal end and is an essential component of the volume-regulated anion channel (VRAC), which controls cellular volume. A heterozygous mutation in L...

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Bibliografski detalji
Izdano u:J Allergy Clin Immunol
Glavni autori: Platt, Craig D., Chou, Janet, Houlihan, Patrick, Badran, Yousef R., Kumar, Lalit, Bainter, Wayne, Poliani, P. Luigi, Perez, Carlos J., Dent, Sharon Y. R., Clapham, David E., Benavides, Fernando, Geha, Raif S.
Format: Artigo
Jezik:Inglês
Izdano: 2017
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6170198/
https://ncbi.nlm.nih.gov/pubmed/28192143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2016.12.974
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