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Computer Folding of RNA Tetraloops: Identification of Key Force Field Deficiencies

The computer aided folding of biomolecules, particularly RNAs, is one of the most difficult challenges in computational structural biology. RNA tetraloops are fundamental RNA motifs playing key roles in RNA folding and RNA-RNA and RNA-protein interactions. Although state-of-the-art Molecular Dynamic...

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Veröffentlicht in:J Chem Theory Comput
Hauptverfasser: Kührová, Petra, Best, Robert B., Bottaro, Sandro, Bussi, Giovanni, Šponer, Jiří, Otyepka, Michal, Banáš, Pavel
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6169534/
https://ncbi.nlm.nih.gov/pubmed/27438572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jctc.6b00300
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