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Computer Folding of RNA Tetraloops: Identification of Key Force Field Deficiencies

The computer aided folding of biomolecules, particularly RNAs, is one of the most difficult challenges in computational structural biology. RNA tetraloops are fundamental RNA motifs playing key roles in RNA folding and RNA-RNA and RNA-protein interactions. Although state-of-the-art Molecular Dynamic...

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Detalles Bibliográficos
Publicado en:J Chem Theory Comput
Main Authors: Kührová, Petra, Best, Robert B., Bottaro, Sandro, Bussi, Giovanni, Šponer, Jiří, Otyepka, Michal, Banáš, Pavel
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6169534/
https://ncbi.nlm.nih.gov/pubmed/27438572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jctc.6b00300
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