Stevioside Prevents Wear Particle-Induced Osteolysis by Inhibiting Osteoclastogenesis and Inflammatory Response via the Suppression of TAK1 Activation

Aseptic loosening and periprosthetic osteolysis are the leading causes of total joint arthroplasty failure, which occurs as a result of chronic inflammatory response and enhanced osteoclast activity. Here we showed that stevioside, a natural compound isolated from Stevia rebaudiana, exhibited preven...

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Bibliografiske detaljer
Udgivet i:Front Pharmacol
Main Authors: Meng, Jiahong, Zhou, Chenhe, Hu, Bin, Luo, Mengmeng, Yang, Yute, Wang, Yangxin, Wang, Wei, Jiang, Guangyao, Hong, Jianqiao, Li, Sihao, Wu, Haobo, Yan, Shigui, Yan, Weiqi
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6169369/
https://ncbi.nlm.nih.gov/pubmed/30319406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01053
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