Additive Effect of Parathyroid Hormone and Zoledronate Acid on Prevention Particle Wears-Induced Implant Loosening by Promoting Periprosthetic Bone Architecture and Strength in an Ovariectomized Rat Model

Implant-generated particle wears are considered as the major cause for the induction of implant loosening, which is more susceptible to patients with osteoporosis. Monotherapy with parathyroid hormone (PTH) or zoledronate acid (ZOL) has been proven efficient for preventing early-stage periprosthetic...

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Detalhes bibliográficos
Main Authors: Chenhe Zhou, Yangxin Wang, Jiahong Meng, Minjun Yao, Huikang Xu, Cong Wang, Fanggang Bi, Hanxiao Zhu, Guang Yang, Mingmin Shi, Shigui Yan, Haobo Wu
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-04-01
Colecção:Frontiers in Endocrinology
Assuntos:
implant loosening
osteolysis
osteoporosis
parathyroid hormone (1-34)
zoledronate (ZOL)
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fendo.2022.871380/full
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