Stevioside Prevents Wear Particle-Induced Osteolysis by Inhibiting Osteoclastogenesis and Inflammatory Response via the Suppression of TAK1 Activation

Aseptic loosening and periprosthetic osteolysis are the leading causes of total joint arthroplasty failure, which occurs as a result of chronic inflammatory response and enhanced osteoclast activity. Here we showed that stevioside, a natural compound isolated from Stevia rebaudiana, exhibited preven...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Meng, Jiahong, Zhou, Chenhe, Hu, Bin, Luo, Mengmeng, Yang, Yute, Wang, Yangxin, Wang, Wei, Jiang, Guangyao, Hong, Jianqiao, Li, Sihao, Wu, Haobo, Yan, Shigui, Yan, Weiqi
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6169369/
https://ncbi.nlm.nih.gov/pubmed/30319406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01053
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