Variable RNA sequencing depth impacts gene signatures and target compound robustness – case study examining brain tumour (glioma) disease progression

Available treatments for glioma have limited effectiveness rendering this a disease of poor clinical outcome. Gene expression profiling can uncover the biological mechanisms underlying disease, information that is crucial for drug development or repurposing. RNA sequencing (RNA-seq) is routinely use...

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Vydáno v:Neuro Oncol
Hlavní autoři: Stupnikov, Dr Alexey, McInerney, Dr Caitríona, O’reilly, Dr Paul, Roddy, Aideen, Dunne, Dr Philip, Gilmore, Mr Alan, Ellis, Dr Hayley, Flannery, Mr Tom, Healy, Dr Estelle, Mcintosh, Dr Stuart, Savage, Dr Kienan, Salto-Tellez, Prof Manuel, Emmert-streib, Dr Frank, Kurian, Dr Kathreena, Prise, Prof Kevin, McArt, Dr Darragh
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168872/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy130.067
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