Immunotolerant p50/NFκB Signaling and Attenuated Hepatic IFNβ Expression Increases Neonatal Sensitivity to Endotoxemia

Sepsis is a major cause of neonatal morbidity and mortality. The current paradigm suggests that neonatal susceptibility to infection is explained by an innate immune response that is functionally immature. Recent studies in adults have questioned a therapeutic role for IFNβ in sepsis; however, the r...

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Dades bibliogràfiques
Publicat a:Front Immunol
Autors principals: McKenna, Sarah, Burey, Taylor, Sandoval, Jeryl, Nguyen, Leanna, Castro, Odalis, Gudipati, Suma, Gonzalez, Jazmin, El Kasmi, Karim C., Wright, Clyde J.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2018
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168645/
https://ncbi.nlm.nih.gov/pubmed/30319651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02210
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