Immunotolerant p50/NFκB Signaling and Attenuated Hepatic IFNβ Expression Increases Neonatal Sensitivity to Endotoxemia

Sepsis is a major cause of neonatal morbidity and mortality. The current paradigm suggests that neonatal susceptibility to infection is explained by an innate immune response that is functionally immature. Recent studies in adults have questioned a therapeutic role for IFNβ in sepsis; however, the r...

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Detaylı Bibliyografya
Yayımlandı:Front Immunol
Asıl Yazarlar: McKenna, Sarah, Burey, Taylor, Sandoval, Jeryl, Nguyen, Leanna, Castro, Odalis, Gudipati, Suma, Gonzalez, Jazmin, El Kasmi, Karim C., Wright, Clyde J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2018
Konular:
Immunology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168645/
https://ncbi.nlm.nih.gov/pubmed/30319651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02210
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