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Lower threshold to NFκB activity sensitizes murine β-cells to streptozotocin
The β-cell response to injury may be as critical for the development of diabetes as the specific insult. In the current study, we use streptozotocin (STZ) to injure the β-cell in order to study the response with a focus on NFκB. MIN6 cells were exposed to STZ (0.5–8mM, 0–24h) ±TNFα (100ng/mL) and ±I...
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| Veröffentlicht in: | J Endocrinol |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8113150/ https://ncbi.nlm.nih.gov/pubmed/33764312 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JOE-21-0047 |
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