CpG‐ODN‐mediated TLR9 innate immune signalling and calcium dyshomeostasis converge on the NFκB inhibitory protein IκBβ to drive IL1α and IL1β expression

Sterile inflammation contributes to many pathological states associated with mitochondrial injury. Mitochondrial injury disrupts calcium homeostasis and results in the release of CpG‐rich mitochondrial DNA. The role of CpG‐stimulated TLR9 innate immune signalling and sterile inflammation is well stu...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Immunology
Autores principales: De Dios, Robyn, Nguyen, Leanna, Ghosh, Sankar, McKenna, Sarah, Wright, Clyde J.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7160659/
https://ncbi.nlm.nih.gov/pubmed/32064589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.13182
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares