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CpG‐ODN‐mediated TLR9 innate immune signalling and calcium dyshomeostasis converge on the NFκB inhibitory protein IκBβ to drive IL1α and IL1β expression

Sterile inflammation contributes to many pathological states associated with mitochondrial injury. Mitochondrial injury disrupts calcium homeostasis and results in the release of CpG‐rich mitochondrial DNA. The role of CpG‐stimulated TLR9 innate immune signalling and sterile inflammation is well stu...

詳細記述

保存先:
書誌詳細
出版年:Immunology
主要な著者: De Dios, Robyn, Nguyen, Leanna, Ghosh, Sankar, McKenna, Sarah, Wright, Clyde J.
フォーマット: Artigo
言語:Inglês
出版事項: John Wiley and Sons Inc. 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7160659/
https://ncbi.nlm.nih.gov/pubmed/32064589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.13182
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