CpG‐ODN‐mediated TLR9 innate immune signalling and calcium dyshomeostasis converge on the NFκB inhibitory protein IκBβ to drive IL1α and IL1β expression

Sterile inflammation contributes to many pathological states associated with mitochondrial injury. Mitochondrial injury disrupts calcium homeostasis and results in the release of CpG‐rich mitochondrial DNA. The role of CpG‐stimulated TLR9 innate immune signalling and sterile inflammation is well stu...

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Veröffentlicht in:Immunology
Hauptverfasser: De Dios, Robyn, Nguyen, Leanna, Ghosh, Sankar, McKenna, Sarah, Wright, Clyde J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
Schlagworte:
Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7160659/
https://ncbi.nlm.nih.gov/pubmed/32064589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.13182
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