Phyllanthusmin derivatives induce apoptosis and reduce tumor burden in high grade serous ovarian cancer by late-stage autophagy inhibition

High grade serous ovarian cancer (HGSOC) is a lethal gynecological malignancy with a need for new therapeutics. Many of the most widely used chemotherapeutic drugs are derived from natural products or their semi-synthetic derivatives. We have developed potent synthetic analogues of a class of compou...

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Veröffentlicht in:Mol Cancer Ther
Hauptverfasser: Young, Alexandria N, Herrera, Denisse, Huntsman, Andrew C., Korkmaz, Melissa A., Lantvit, Daniel D., Mazumder, Sarmistha, Kolli, Shamalatha, Coss, Christopher C., King, Salane, Wang, Hongyan, Swanson, Steven M., Kinghorn, A. Douglas, Zhang, Xiaoli, Phelps, Mitch A., Aldrich, Leslie N., Fuchs, James R., Burdette, Joanna E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168422/
https://ncbi.nlm.nih.gov/pubmed/30018048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-1195
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