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Phyllanthusmin derivatives induce apoptosis and reduce tumor burden in high grade serous ovarian cancer by late-stage autophagy inhibition

High grade serous ovarian cancer (HGSOC) is a lethal gynecological malignancy with a need for new therapeutics. Many of the most widely used chemotherapeutic drugs are derived from natural products or their semi-synthetic derivatives. We have developed potent synthetic analogues of a class of compou...

詳細記述

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書誌詳細
出版年:Mol Cancer Ther
主要な著者: Young, Alexandria N, Herrera, Denisse, Huntsman, Andrew C., Korkmaz, Melissa A., Lantvit, Daniel D., Mazumder, Sarmistha, Kolli, Shamalatha, Coss, Christopher C., King, Salane, Wang, Hongyan, Swanson, Steven M., Kinghorn, A. Douglas, Zhang, Xiaoli, Phelps, Mitch A., Aldrich, Leslie N., Fuchs, James R., Burdette, Joanna E.
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168422/
https://ncbi.nlm.nih.gov/pubmed/30018048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-1195
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