Synthesis and antiproliferative activity of derivatives of the phyllanthusmin class of arylnaphthalene lignan lactones

A series of arylnaphthalene lignan lactones based on the structure of the phyllanthusmins, a class of potent natural products possessing diphyllin as the aglycone, has been synthesized and screened for activity against multiple cancer cell lines. SAR exploration was performed on both the carbohydrat...

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Publicat a:Bioorg Med Chem
Autors principals: Woodard, John L., Huntsman, Andrew C., Patel, Pratiq A., Chai, Hee-Byung, Kanagasabai, Ragu, Karmahapatra, Soumendrakrishna, Young, Alexandria N., Ren, Yulin, Cole, Malcolm S., Herrera, Denisse, Yalowich, Jack C., Kinghorn, A. Douglas, Burdette, Joanna E., Fuchs, James R.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5962029/
https://ncbi.nlm.nih.gov/pubmed/29656990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2018.03.033
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