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Development of a tetravalent anti-GPA33/anti-CD3 bispecific antibody for colorectal cancers

Despite progress in the treatment of colorectal cancer (CRC), curing metastatic CRC (mCRC) remains a major unmet medical need worldwide. Here we described a T cell engaging bispecific antibody (T-BsAb) to redirect polyclonal cytotoxic T cells to eradicate CRC. A33, a murine antibody specific for GPA...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Mol Cancer Ther
Hauptverfasser: Wu, Zhihao, Guo, Hong-Fen, Xu, Hong, Cheung, Nai-Kong V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168351/
https://ncbi.nlm.nih.gov/pubmed/30082472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-0026
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