Caricamento...
GSK3-β promotes calpain-1–mediated desmin filament depolymerization and myofibril loss in atrophy
Myofibril breakdown is a fundamental cause of muscle wasting and inevitable sequel of aging and disease. We demonstrated that myofibril loss requires depolymerization of the desmin cytoskeleton, which is activated by phosphorylation. Here, we developed a mass spectrometry–based kinase-trap assay and...
Salvato in:
| Pubblicato in: | J Cell Biol |
|---|---|
| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Rockefeller University Press
2018
|
| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6168250/ https://ncbi.nlm.nih.gov/pubmed/30061109 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201802018 |
| Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !
|