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GSK3-β promotes calpain-1–mediated desmin filament depolymerization and myofibril loss in atrophy
Myofibril breakdown is a fundamental cause of muscle wasting and inevitable sequel of aging and disease. We demonstrated that myofibril loss requires depolymerization of the desmin cytoskeleton, which is activated by phosphorylation. Here, we developed a mass spectrometry–based kinase-trap assay and...
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| Publicado no: | J Cell Biol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Rockefeller University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6168250/ https://ncbi.nlm.nih.gov/pubmed/30061109 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201802018 |
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