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Myofibril breakdown during atrophy is a delayed response requiring the transcription factor PAX4 and desmin depolymerization
A hallmark of muscle atrophy is the excessive degradation of myofibrillar proteins primarily by the ubiquitin proteasome system. In mice, during the rapid muscle atrophy induced by fasting, the desmin cytoskeleton and the attached Z-band–bound thin filaments are degraded after ubiquitination by the...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5338431/ https://ncbi.nlm.nih.gov/pubmed/28096335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1612988114 |
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