A signaling hub of insulin receptor, dystrophin glycoprotein complex and plakoglobin regulates muscle size

Signaling through the insulin receptor governs central physiological functions related to cell growth and metabolism. Here we show by tandem native protein complex purification approach and super-resolution STED microscopy that insulin receptor activity requires association with the fundamental stru...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Eid Mutlak, Yara, Aweida, Dina, Volodin, Alexandra, Ayalon, Bar, Dahan, Nitsan, Parnis, Anna, Cohen, Shenhav
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7070008/
https://ncbi.nlm.nih.gov/pubmed/32170063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14895-9
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