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A signaling hub of insulin receptor, dystrophin glycoprotein complex and plakoglobin regulates muscle size

Signaling through the insulin receptor governs central physiological functions related to cell growth and metabolism. Here we show by tandem native protein complex purification approach and super-resolution STED microscopy that insulin receptor activity requires association with the fundamental stru...

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Vydáno v:Nat Commun
Hlavní autoři: Eid Mutlak, Yara, Aweida, Dina, Volodin, Alexandra, Ayalon, Bar, Dahan, Nitsan, Parnis, Anna, Cohen, Shenhav
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7070008/
https://ncbi.nlm.nih.gov/pubmed/32170063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14895-9
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