Cargando...

USP1 deubiquitinates Akt to inhibit PI3K‐Akt‐FoxO signaling in muscle during prolonged starvation

PI3K‐Akt‐FoxO‐mTOR signaling is the central pathway controlling growth and metabolism in all cells. Ubiquitination of the protein kinase Akt prior to its phosphorylation is required for PI3K‐Akt activity. Here, we found that the deubiquitinating (DUB) enzyme USP1 removes K63‐linked polyubiquitin cha...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:EMBO Rep
Main Authors: Goldbraikh, Dana, Neufeld, Danielle, Eid‐Mutlak, Yara, Lasry, Inbal, Gilda, Jennifer E, Parnis, Anna, Cohen, Shenhav
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2020
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7132338/
https://ncbi.nlm.nih.gov/pubmed/32133736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201948791
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!