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USP1 deubiquitinates Akt to inhibit PI3K‐Akt‐FoxO signaling in muscle during prolonged starvation

PI3K‐Akt‐FoxO‐mTOR signaling is the central pathway controlling growth and metabolism in all cells. Ubiquitination of the protein kinase Akt prior to its phosphorylation is required for PI3K‐Akt activity. Here, we found that the deubiquitinating (DUB) enzyme USP1 removes K63‐linked polyubiquitin cha...

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Bibliographic Details
Published in:EMBO Rep
Main Authors: Goldbraikh, Dana, Neufeld, Danielle, Eid‐Mutlak, Yara, Lasry, Inbal, Gilda, Jennifer E, Parnis, Anna, Cohen, Shenhav
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7132338/
https://ncbi.nlm.nih.gov/pubmed/32133736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201948791
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