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Trim32 reduces PI3K–Akt–FoxO signaling in muscle atrophy by promoting plakoglobin–PI3K dissociation

Activation of the PI3K–Akt–FoxO pathway induces cell growth, whereas its inhibition reduces cell survival and, in muscle, causes atrophy. Here, we report a novel mechanism that suppresses PI3K–Akt–FoxO signaling. Although skeletal muscle lacks desmosomes, it contains multiple desmosomal components,...

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Библиографические подробности
Главные авторы: Cohen, Shenhav, Lee, Donghoon, Zhai, Bo, Gygi, Steven P., Goldberg, Alfred L.
Формат: Artigo
Язык:Inglês
Опубликовано: The Rockefeller University Press 2014
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3941042/
https://ncbi.nlm.nih.gov/pubmed/24567360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201304167
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