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Trim32 reduces PI3K–Akt–FoxO signaling in muscle atrophy by promoting plakoglobin–PI3K dissociation

Activation of the PI3K–Akt–FoxO pathway induces cell growth, whereas its inhibition reduces cell survival and, in muscle, causes atrophy. Here, we report a novel mechanism that suppresses PI3K–Akt–FoxO signaling. Although skeletal muscle lacks desmosomes, it contains multiple desmosomal components,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Cohen, Shenhav, Lee, Donghoon, Zhai, Bo, Gygi, Steven P., Goldberg, Alfred L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3941042/
https://ncbi.nlm.nih.gov/pubmed/24567360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201304167
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