Circulating HLA-DR(+)CD4(+) effector memory T cells resistant to CCR5 and PD-L1 mediated suppression compromise regulatory T cell function in tuberculosis

Chronic T cell activation is a hallmark of pulmonary tuberculosis (PTB). The mechanisms underpinning this important phenomenon are however, poorly elucidated, though known to rely on control of T effector cells (Teff) by regulatory T cells (Treg). Our studies show that circulating natural Treg cells...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Ahmed, Asma, Adiga, Vasista, Nayak, Soumya, Uday Kumar, J. Anto Jesuraj, Dhar, Chirag, Sahoo, Pravat Nalini, Sundararaj, Bharath K., Souza, George D., Vyakarnam, Annapurna
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6166982/
https://ncbi.nlm.nih.gov/pubmed/30231065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007289
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