Lataa...

Nur77 variants solely comprising the amino-terminal domain activate hypoxia-inducible factor-1α and affect bone marrow homeostasis in mice and humans

Gene targeting via homologous recombination can occasionally result in incomplete disruption of the targeted gene. Here, we show that a widely used Nur77-deficient transgenic mouse model expresses a truncated protein encoding for part of the N-terminal domain of nuclear receptor Nur77. This truncate...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Koenis, Duco S., Medzikovic, Lejla, Vos, Mariska, Beldman, Thijs J., van Loenen, Pieter B., van Tiel, Claudia M., Hamers, Anouk A. J., Otermin Rubio, Iker, de Waard, Vivian, de Vries, Carlie J. M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2018
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6166732/
https://ncbi.nlm.nih.gov/pubmed/30111591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002720
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!