Nur77 variants solely comprising the amino-terminal domain activate hypoxia-inducible factor-1α and affect bone marrow homeostasis in mice and humans

Gene targeting via homologous recombination can occasionally result in incomplete disruption of the targeted gene. Here, we show that a widely used Nur77-deficient transgenic mouse model expresses a truncated protein encoding for part of the N-terminal domain of nuclear receptor Nur77. This truncate...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Koenis, Duco S., Medzikovic, Lejla, Vos, Mariska, Beldman, Thijs J., van Loenen, Pieter B., van Tiel, Claudia M., Hamers, Anouk A. J., Otermin Rubio, Iker, de Waard, Vivian, de Vries, Carlie J. M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2018
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6166732/
https://ncbi.nlm.nih.gov/pubmed/30111591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002720
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars