Deficiency of Nuclear Receptor Nur77 Aggravates Mouse Experimental Colitis by Increased NFκB Activity in Macrophages

Nuclear receptor Nur77, also referred to as NR4A1 or TR3, plays an important role in innate and adaptive immunity. Nur77 is crucial in regulating the T helper 1/regulatory T-cell balance, is expressed in macrophages and drives M2 macrophage polarization. In this study we aimed to define the function...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Hamers, Anouk A. J., van Dam, Laura, Teixeira Duarte, José M., Vos, Mariska, Marinković, Goran, van Tiel, Claudia M., Meijer, Sybren L., van Stalborch, Anne-Marieke, Huveneers, Stephan, te Velde, Anje A., de Jonge, Wouter J., de Vries, Carlie J. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524678/
https://ncbi.nlm.nih.gov/pubmed/26241646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0133598
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