Deficiency of Nuclear Receptor Nur77 Aggravates Mouse Experimental Colitis by Increased NFκB Activity in Macrophages

Nuclear receptor Nur77, also referred to as NR4A1 or TR3, plays an important role in innate and adaptive immunity. Nur77 is crucial in regulating the T helper 1/regulatory T-cell balance, is expressed in macrophages and drives M2 macrophage polarization. In this study we aimed to define the function...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Hamers, Anouk A. J., van Dam, Laura, Teixeira Duarte, José M., Vos, Mariska, Marinković, Goran, van Tiel, Claudia M., Meijer, Sybren L., van Stalborch, Anne-Marieke, Huveneers, Stephan, te Velde, Anje A., de Jonge, Wouter J., de Vries, Carlie J. M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2015
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524678/
https://ncbi.nlm.nih.gov/pubmed/26241646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0133598
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