Structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase–dihydropteroate synthase from Plasmodium vivax sheds light on drug resistance

The genomes of the malaria-causing Plasmodium parasites encode a protein fused of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK) and dihydropteroate synthase (DHPS) domains that catalyze sequential reactions in the folate biosynthetic pathway. Whereas higher organisms derive folate from...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Yogavel, Manickam, Nettleship, Joanne E., Sharma, Akansha, Harlos, Karl, Jamwal, Abhishek, Chaturvedi, Rini, Sharma, Manmohan, Jain, Vitul, Chhibber-Goel, Jyoti, Sharma, Amit
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6166723/
https://ncbi.nlm.nih.gov/pubmed/30104413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004558
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados