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Crystal Structure of the 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase•Dihydropteroate Synthase Bifunctional Enzyme from Francisella tularensis

The 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK) and dihydropteroate synthase (DHPS) enzymes catalyze sequential metabolic reactions in the folate biosynthetic pathway of bacteria and lower eukaryotes. Both enzymes represent validated targets for the development of novel anti-microbial...

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Main Authors: Pemble, Charles W., Mehta, Perdeep K., Mehra, Smriti, Li, Zhenmei, Nourse, Amanda, Lee, Richard E., White, Stephen W.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2994781/
https://ncbi.nlm.nih.gov/pubmed/21152407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014165
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