The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase

6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK) is an essential enzyme in the microbial folate biosynthetic pathway. This pathway has proven to be an excellent target for antimicrobial development, but widespread resistance to common therapeutics including the sulfa drugs has stimulated i...

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Vydáno v:Bioorg Med Chem
Hlavní autoři: Yun, Mi-Kyung, Hoagland, Daniel, Kumar, Gyanendra, Waddell, M. Brett, Rock, Charles O., Lee, Richard E., White, Stephen W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4269157/
https://ncbi.nlm.nih.gov/pubmed/24613625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.02.022
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