The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase

6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK) is an essential enzyme in the microbial folate biosynthetic pathway. This pathway has proven to be an excellent target for antimicrobial development, but widespread resistance to common therapeutics including the sulfa drugs has stimulated i...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Yun, Mi-Kyung, Hoagland, Daniel, Kumar, Gyanendra, Waddell, M. Brett, Rock, Charles O., Lee, Richard E., White, Stephen W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4269157/
https://ncbi.nlm.nih.gov/pubmed/24613625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.02.022
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