Bisubstrate inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: Transition state analogs for high affinity binding

6-Hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK) is a key enzyme in the folate biosynthesis pathway. It catalyzes pyrophosphoryl transfer from ATP to 6-hydroxymethyl-7,8-dihydropterin (HP). HPPK is essential for microorganisms but absent in mammals; therefore, it is an attractive target fo...

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Publicado en:Bioorg Med Chem
Main Authors: Shi, Genbin, Shaw, Gary X., Zhu, Fengxia, Tarasov, Sergey G., Ji, Xinhua
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7855645/
https://ncbi.nlm.nih.gov/pubmed/33199204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2020.115847
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