Structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase–dihydropteroate synthase from Plasmodium vivax sheds light on drug resistance

The genomes of the malaria-causing Plasmodium parasites encode a protein fused of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK) and dihydropteroate synthase (DHPS) domains that catalyze sequential reactions in the folate biosynthetic pathway. Whereas higher organisms derive folate from...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Yogavel, Manickam, Nettleship, Joanne E., Sharma, Akansha, Harlos, Karl, Jamwal, Abhishek, Chaturvedi, Rini, Sharma, Manmohan, Jain, Vitul, Chhibber-Goel, Jyoti, Sharma, Amit
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2018
Teme:
Protein Structure and Folding
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6166723/
https://ncbi.nlm.nih.gov/pubmed/30104413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004558
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