Immunomodulatory drugs downregulate IKZF1 leading to expansion of hematopoietic progenitors with concomitant block of megakaryocytic maturation

The immunomodulatory drugs, lenalidomide and pomalidomide yield high response rates in multiple myeloma patients, but are associated with a high rate of thrombocytopenia and increased risk of secondary hematologic malignancies. Here, we demonstrate that the immunomodulatory drugs induce self-renewal...

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Veröffentlicht in:Haematologica
Hauptverfasser: Liu, Ailing, Li, Shirong, Donnenberg, Vera, Fu, Jing, Gollin, Susanne M., Ma, Huihui, Lu, Caisheng, Stolz, Donna B., Mapara, Markus Y., Monaghan, Sara A., Lentzsch, Suzanne
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ferrata Storti Foundation 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6165797/
https://ncbi.nlm.nih.gov/pubmed/29954930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.188227
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