IMiD immunomodulatory compounds block C/EBPβ translation through eIF4E down-regulation resulting in inhibition of MM

Immunomodulatory derivatives of thalidomide (IMiD compounds), such as pomalidomide and lenalidomide, are highly active in multiple myeloma (MM) treatment. However, the precise mechanisms of action and resistance in MM are unresolved. Here we show that IMiD compounds down-regulate CCAAT/enhancer-bind...

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Bibliografiske detaljer
Main Authors: Li, Shirong, Pal, Rekha, Monaghan, Sara A., Schafer, Peter, Ouyang, Hongjiao, Mapara, Markus, Galson, Deborah L., Lentzsch, Suzanne
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2011
Fag:
Lymphoid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3357942/
https://ncbi.nlm.nih.gov/pubmed/21389327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-10-314278
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