IMiD immunomodulatory compounds block C/EBPβ translation through eIF4E down-regulation resulting in inhibition of MM

Immunomodulatory derivatives of thalidomide (IMiD compounds), such as pomalidomide and lenalidomide, are highly active in multiple myeloma (MM) treatment. However, the precise mechanisms of action and resistance in MM are unresolved. Here we show that IMiD compounds down-regulate CCAAT/enhancer-bind...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Li, Shirong, Pal, Rekha, Monaghan, Sara A., Schafer, Peter, Ouyang, Hongjiao, Mapara, Markus, Galson, Deborah L., Lentzsch, Suzanne
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2011
Onderwerpen:
Lymphoid Neoplasia
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3357942/
https://ncbi.nlm.nih.gov/pubmed/21389327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-10-314278
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items