Absence of Stat1 in donor CD4(+) T cells promotes the expansion of Tregs and reduces graft-versus-host disease in mice

STAT1 is the main signal transducer for type I and II IFNs and plays a central role in the regulation of innate and adaptive immune responses. We used Stat1-deficient mice to test the role of donor Stat1 in MHC-matched minor histocompatibility antigen–mismatched (mHA-mismatched) and fully MHC-mismat...

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Detalhes bibliográficos
Main Authors: Ma, Huihui, Lu, Caisheng, Ziegler, Judith, Liu, Ailing, Sepulveda, Antonia, Okada, Hideho, Lentzsch, Suzanne, Mapara, Markus Y.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223821/
https://ncbi.nlm.nih.gov/pubmed/21670504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43706
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