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Pyridone luciferins and mutant luciferases for bioluminescence imaging

New applications of bioluminescence imaging require an expanded set of luciferase enzymes and luciferin substrates. Here we report two novel luciferins for use in vitro and in cells. These molecules comprise regioisomeric pyridone cores that can be accessed from a common synthetic route. The analogs...

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Bibliographic Details
Published in:Chembiochem
Main Authors: Zhang, Brendan S., Jones, Krysten A., McCutcheon, David C., Prescher, Jennifer A.
Format: Artigo
Language:Inglês
Published: 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6163054/
https://ncbi.nlm.nih.gov/pubmed/29384255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201700542
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