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Selection for Protein Stability Enriches for Epistatic Interactions
A now classical argument for the marginal thermodynamic stability of proteins explains the distribution of observed protein stabilities as a consequence of an entropic pull in protein sequence space. In particular, most sequences that are sufficiently stable to fold will have stabilities near the fo...
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| Udgivet i: | Genes (Basel) |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
MDPI
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6162820/ https://ncbi.nlm.nih.gov/pubmed/30134605 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes9090423 |
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