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Selection for Protein Stability Enriches for Epistatic Interactions

A now classical argument for the marginal thermodynamic stability of proteins explains the distribution of observed protein stabilities as a consequence of an entropic pull in protein sequence space. In particular, most sequences that are sufficiently stable to fold will have stabilities near the fo...

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Dettagli Bibliografici
Pubblicato in:Genes (Basel)
Autori principali: Posfai, Anna, Zhou, Juannan, Plotkin, Joshua B., Kinney, Justin B., McCandlish, David M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6162820/
https://ncbi.nlm.nih.gov/pubmed/30134605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes9090423
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