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Epistatically Interacting Substitutions Are Enriched during Adaptive Protein Evolution

Most experimental studies of epistasis in evolution have focused on adaptive changes—but adaptation accounts for only a portion of total evolutionary change. Are the patterns of epistasis during adaptation representative of evolution more broadly? We address this question by examining a pair of prot...

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Bibliografische gegevens
Hoofdauteurs: Gong, Lizhi Ian, Bloom, Jesse D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2014
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4014419/
https://ncbi.nlm.nih.gov/pubmed/24811236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004328
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