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Mutational effects on stability are largely conserved during protein evolution
Protein stability and folding are the result of cooperative interactions among many residues, yet phylogenetic approaches assume that sites are independent. This discrepancy has engendered concerns about large evolutionary shifts in mutational effects that might confound phylogenetic approaches. Her...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3876214/ https://ncbi.nlm.nih.gov/pubmed/24324165 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1314781111 |
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