Germinal Center B Cells Replace Their Antigen Receptors in Dark Zones and Fail Light Zone Entry when Immunoglobulin Gene Mutations are Damaging

Adaptive immunity involves the development of bespoke antibodies in germinal centers (GCs) through immunoglobulin somatic hypermutation (SHM) in GC dark zones (DZs) and clonal selection in light zones (LZs). Accurate selection requires that cells fully replace surface B cell receptors (BCRs) followi...

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Bibliographic Details
Published in:Immunity
Main Authors: Stewart, Isabelle, Radtke, Daniel, Phillips, Bethan, McGowan, Simon J., Bannard, Oliver
Format: Artigo
Language:Inglês
Published: Cell Press 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6162340/
https://ncbi.nlm.nih.gov/pubmed/30231983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.08.025
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