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Expression of the Plasma Cell Transcriptional Regulator Blimp-1 by Dark Zone Germinal Center B Cells During Periods of Proliferation

Long-lived plasma cells (PCs) develop in germinal centers (GCs) by the differentiation of affinity matured B cells. Antibody affinity maturation involves iterative rounds of somatic hypermutation in dark zones (DZs) and selection in light zones (LZs), however the details of where, when and how PC co...

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Vydáno v:Front Immunol
Hlavní autoři: Radtke, Daniel, Bannard, Oliver
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6334666/
https://ncbi.nlm.nih.gov/pubmed/30687317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.03106
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