Detection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children’s Oncology Group

BACKGROUND: New prognostic markers are needed to identify patients with Ewing sarcoma (EWS) and osteosarcoma unlikely to benefit from standard therapy. We describe the incidence and association with outcome of circulating tumour DNA (ctDNA) using next-generation sequencing (NGS) assays. METHODS: A N...

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izdano v:Br J Cancer
Main Authors: Shulman, David S., Klega, Kelly, Imamovic-Tuco, Alma, Clapp, Andrea, Nag, Anwesha, Thorner, Aaron R., Van Allen, Eliezer, Ha, Gavin, Lessnick, Stephen L., Gorlick, Richard, Janeway, Katherine A., Leavey, Patrick J., Mascarenhas, Leo, London, Wendy B., Vo, Kieuhoa T., Stegmaier, Kimberly, Hall, David, Krailo, Mark D., Barkauskas, Donald A., DuBois, Steven G., Crompton, Brian D.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6162271/
https://ncbi.nlm.nih.gov/pubmed/30131550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-018-0212-9
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